However, in a subset of patients focal liver lesions may develop, presenting with a wide range of imaging features. Wilson disease (WD) is an autosomal recessive inherited disorder caused by dysfunction of the copper transporter ATP7B, which is expressed mainly in hepatocytes and is critical for hepatic copper homeostasis. If there are neurological symptoms, magnetic resonance imaging (MRI) of the brain is usually performed; this shows structural … The analysis of biopsied liver tissue with a microscope detects liver damage, which often shows a pattern unique to Wilson disease. Hepatic involvement in Wilson disease (WD) manifests as a diffuse chronic disease in the majority of patients. Copper deposition resulting from Wilson's disease occurs in the periportal regions and along the hepatic sinusoids and incites an inflammatory reaction that can lead to cirrhosis. 14). Wilson disease is a genetic disorder that prevents the body from removing extra copper, causing copper to build up in the liver, brain, eyes, and other organs. akhano@tr.net We present unusual imaging findings in the liver of a patient with Wilson's disease. Discussion Wilson’s disease is a rare genetic disorder characterized by deficiency of ceruloplasmin affecting copper metabolism, leading to excessive systemic copper deposition, particularly in liver and brain. Copper has no ferromagnetic effect on MR imaging because copper in hepatocytes may combine with proteins. However, the clinical applications of MR imaging features of the liver in Wilson’s disease have not yet been established. Wilson’s disease is a rare genetic disorder that causes a toxic buildup of copper in the liver and other organs, especially the brain, kidneys, and eyes. On US, the liver contours were irregular and its echogenicity was increased with multiple, small hypo- and hyperechoic nodules. 1-3 Defective ATP7B function causes impaired biliary copper excretion and pathological accumulation of copper in the liver and central nervous system. Author information: (1)Department of Radiology, Hacettepe University, Sihhiye/Ankara, 06100 Turkey. Wilson's disease (WD) is characterised by a deleterious accumulation of copper in the liver and brain. To describe the magnetic resonance imaging (MRI) presentation of liver involvement in adult patients with Wilson disease (WD) and determine the most indicative appearance of this condition on MRI using a retrospective case–control study. Wilson's disease is a rare inherited disorder that causes copper to accumulate in your liver, brain and other vital organs. Most people with Wilson's disease are diagnosed between the ages of 5 and 35, but it can affect younger and older people, as well. The diagnosis of Wilson’s disease was subsequently confirmed after biochemical investigations. Without treatment, high copper levels can cause life-threatening organ damage. MRI examinations of 23 adult patients with WD (14 men, 9 women; mean age = 40.4 years) were analyzed by two blinded observers and compared to … The most common finding of Wilson's disease is cirrhotic change. In these reports, it has been stated that the nodules and contour irregularity may regress, or even, disappear after the treatment [7,29,30].In conclusion, liver injury in the Wilson's disease may be detected with several imaging modalities and this may potentially obviate the need for biopsy and allows a non-invasive diagnosis. Defective ATP7B function causes impaired biliary copper excretion and pathological accumulation of copper hepatocytes. And other vital organs hyperechoic nodules damage, which often shows a pattern unique to Wilson disease clinical of... 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