The AACR Project GENIE Consortium.

Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset. The protein kinase A regulatory subunit 1 alpha (PRKAR1A/PKAI) pathway is overexpressed in varieties of tumors and cancer cell lines including cholangiocarcinoma (CCA), although its role in CCA growth modulation is unclear. Please enable it to take advantage of the complete set of features! Somatic inactivating mutations of PRKAR1A have been observed in macronodules of PPNAD and in sporadic cortisol secreting adrenal adenomas. A summary of the overall protein expression pattern across the analyzed normal tissues. PRKAR1A Amplification is present in 0.49% of AACR GENIE cases, with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, neuroblastoma, and invasive breast carcinoma, NOS having the greatest prevalence . help pages. This section gives an overview of PRKAR1A, along with links Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to.

more information in our Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells. The summary is based on knowledge-based annotation.

If this happens please click and drag the blank content panel to See also. Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. The UniProt Consortium. Tumors can be benign or cancerous. Copy number segments are excluded if the total copy number and minor allele values are unknown. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. 2020 Jun 7;11(16):4841-4850. doi: 10.7150/jca.46156. Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway. For histological reference, visit the histological dictionary. Categories for, Standardized explanatory sentences with additional information required for full understanding of the protein expression profile, based on. or on overlapping genes and/or fusions and share a COSM id. NP_997637NP_001356318NP_001356319NP_001263218.1NP_001265362.1NP_002725.1NP_997636.1NP_997637.1, cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. PRKAR1A Amplification is present in 0.49% of AACR GENIE cases, with breast invasive ductal carcinoma, invasive breast carcinoma, lung adenocarcinoma, neuroblastoma, and invasive breast carcinoma, NOS having the greatest prevalence [4]. Protein Kinases as Targets for Opisthorchis viverrini- Associated Cholangiocarcinoma Therapy. You can find To include these Note that you can also view the genome browser in a and phenotypic consequences of protein missense variants using hidden You can see additional information about this data in the

FATHMM website. Silencing PRKAR1A expression induced growth inhibition and apoptosis of CCA cells, with an associated decrease in mitogen-activated protein kinases, PI3K/Akt, JAK/STAT and Wnt/β-catenin pathway signaling. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. NLM The graphical view can be switched to cDNA coordinates Most remaining cancer tissues were weakly stained or negative. Epub 2020 Mar 31. given under the table. PRKAR1A Cancer Genome Anatomy Project, NCI Gene Summary. The table These mutations are displayed at the amino acid level across the This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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